Endocrine Abstracts

Introduction: Human fat mass and obesity-associated gene (FTO) gene expression are associated with body mass index and type 2 diabetes. It is unknown whether lifestyle factors, such as physical activity, can attenuate weight gain and obesity by contribution to the FTO gene regulation. The objective of the present study was to investigate the association between habitual physical activity and the FTO gene expression among morbid obese and non-obese subjects.<p class="abstex...

New evidence indicated that miRNAs may contribute to the regulation of energy balance and metabolic homeostasis, by controlling a wide range of metabolic pathways. miR-143 and miR-34a are the best studied among the miRNAs linked to adipose tissue regulation. Dietary intake, among many other environmental factors, is a key player that can induce epigenetic changes. The aim of the study was to investigate the association of the miR-143 and miR-34a expression in visceral and subc...

Introduction: Adipocytokines secreted by adipose tissue are suggested to play a role in the development of obesity-related complications. Leptin is mainly produced and secreted by adipose tissue and appears as an important regulator of energy balance. The relationship between leptin levels and energy expenditure remain unclear. Energy expenditure related to physical activity (PA) is the most variable part of total energy expenditure. There is some evidence tha...

Background and Objective: Several animal studies showed the expression of peroxisome proliferator activated receptor-gamma (PPAR gamma) in adipocytes among rats fed with high-fat diet was higher than those fed with normal diet. However, there are no human studies to support this. The objective of the present study was to investigate the association between the PPAR gamma expression in adipose tissue and intake of hydrogenated and non-hydrogenated vegetable oils and butter....

Objective: To investigate whether peroxisome proliferator-activated receptor gamma (PPAR-gamma) gene expression in visceral and subcutaneous adipose tissue was related to intake of several fatty acid intakes.Methods: For the current study 97 subjects (41 non-obese, 18 obese, and 38 morbid obese) were selected. All of the subjects were free of diabetes and cancers and without using anti-lipid medication. Visceral and subcutaneous adipose tissues were obta...